Hormone excretion and liver function in the gynecomastia of leprosy

1- Hormone excretion and liver function were studied in 18 lepromatous cases with gynecomastia, 20 lepromatous cases without gynecomastia, 20 tuberculoid cases, and 20 normal Bantu controls. 2- Tuberculoid cases showed minimal liver dysfunction, while marked liver dysfunction was found in lepromatous cases whether they had gynecomastia or not. 3- Hormone excretion is discussed in relation to the disease process and liver function. 4- No correlation could be found between gynecomastia and liver dysfunction or estrogen excretion, or between liver dysfunction and estrogen excretion. 5- The finding of a Klinefelter-like syndrome in four cases is mentioned.